Cholera continues to be a significant problem in humanitarian settings, with recent outbreaks in displaced populations in South Sudan, Yemen, Cameroon, Nigeria, Tanzania, Uganda, Haiti, and Iraq. The success of cholera prevention and control in refugee camps over the past 2 decades highlights the possibility of managing this deadly disease, even in complicated humanitarian crises. Sphere standards and associated control strategies have been shown to be effective in humanitarian crisis settings, dramatically reducing the number and size of outbreaks seen in refugee camps after the North Kivu disaster. Although other vulnerable populations, particularly IDPs, continue to suffer from a substantial cholera burden, application of these strategies in combination with supplementary tools such as OCV have the potential to substantially reduce cholera cases and deaths in line with the 2030 goal of reducing cholera deaths by 90% worldwide.